منابع مشابه
Elastin in the Liver
A characteristic feature of liver cirrhosis is the accumulation of large amounts of connective tissue with the prevailing content of type I collagen. Elastin is a minor connective tissue component in normal liver but it is actively synthesized by hepatic stellate cells and portal fibroblasts in diseased liver. The accumulation of elastic fibers in later stages of liver fibrosis may contribute t...
متن کاملCrosslinked alpha-elastin biomaterials: towards a processable elastin mimetic scaffold.
Elastin is a critical biochemical and biomechanical component of vascular tissue. However, elastin is also highly insoluble and therefore difficult to process into new biomaterials. We present a simple approach for synthesizing elastin-based materials from two commercially available and water-soluble components: alpha-elastin and a diepoxy crosslinker. Reaction pH was shown to modulate the degr...
متن کاملElastin in the Avian Lungs
Elastic fibres play an important role in the pulmonary development process. The overall goal of this work was to quantify elastin in chicken lungs, using domestic fowl (Gallus gallus) as an experimental model, from the 14 th day of hatching until the 42 nd after hatchling. As analytical methodologies we used high-performance liquid chromatography (HPLC) and a colorimetric method based on the us...
متن کاملChanges in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease
BACKGROUND COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican. This study aimed to determine if alveoli of patients with mild to moderate COPD co...
متن کاملInhibition of MicroRNA-29 Enhances Elastin Levels in Cells Haploinsufficient for Elastin and in Bioengineered Vessels
Objective—The goal of this study was to determine whether antagonizing microRNA (miR)-29 enhances elastin (ELN) levels in cells and tissues lacking ELN. Methods and Results—miR-29 mimics reduced ELN levels in fibroblasts and smooth muscle cells, whereas miR-29 inhibition increased ELN levels. Antagonism of miR-29 also increased ELN levels in cells from patients haploinsufficient for ELN and in ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1982
ISSN: 0022-202X
DOI: 10.1038/jid.1982.29